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In a murine model, which was synergistic with GPX4 inhibition, Aldehyde Dehydrogenase 3 Family Member A2 (Aldh3a2) depletion was shown to induce ferroptosis [54]

305 : E271E281

Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity

34,35 Studies demonstrated that HFD/STZ induces hyperglycemia, which stimulates insulin secretion, consequently activating hepatic lipogenesis and cholesterol excretion, thereby disrupting lipid metabolism, manifested as hyperlipidemia